Transtibial Patient Dx with Pemphigus

Transtibial Patient Dx with Pemphigus

Doug Reichert CP

I have a prospective patient that has had a transtibial amputation and has
been diagnosed with pemphigus, which is:

Pemphigus is a group of rare autimmune blistering diseases of the skin
and/or mucous membranes.Our immune system produces antibodies that normally
attack hostile viruses and bacteria in an effort to keep us healthy. In a
person with pemphigus, however, the immune system mistakenly perceives the
cells in skin and/or mucous membrane as foreign, and attacks them. Antibodies
that attack one’s own cells are called autoantibodies. The part of the cells
that are attacked in pemphigus are proteins called desmogleins. Desmogleins
form the glue that attaches adjacent skin cells, keeping the skin intact.When
auto-antibodies attack desmogliens, the cells become separated from each
other. The skin virtually becomes unglued. This causes burn-like lesions or
blisters that do not heal. In some cases, these blisters can cover a
significant area of the skin.
    

Has anyone fit a patient with this condition with success or failure? Any
comments or suggestions would be appreciated.

Thanks

Doug Reichert, CP, LP
262 654 4300